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PART II: HOW A VIRUS WORKS 

THIS CONTENT IS NOT INTENDED FOR CONSUMERS

The content of this webpage is intended to provide formulators and manufacturers with an overview of the peer-reviewed scientific data available on pure Australian Tea Tree Oil and its reported antiviral and virucidal properties. These data do not suggest that any formulation containing pure Australian Tea Tree Oil will exhibit antiviral or virucidal activity. These data do not remove a manufacturer’s responsibility to conduct appropriate trials to verify safety and efficacy.

If you missed Part I: Tea Tree Oil as an Anti-Viral

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Coronavirus

The anatomy of a typical coronavirus can be illustrated as shown. The viral envelope (blue) is a lipid bilayer that surrounds the nucleocapsid protein and RNA genome, which together form the virus’s genetic material.

Embedded within and extending through the lipid envelope are structural proteins, including spike proteins (pink, pin-like structures) and various membrane proteins that play key roles in viral stability and infection.

One of the most important components for viral transmission is the haemagglutinin glycoprotein complex (HA), which is involved in host cell recognition and attachment.

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Routine Viral Transfer

A properly functioning haemagglutinin glycoprotein complex enables viral attachment to a host cell.

Importantly, changes in pH induce a conformational change in the HA2 protein, preparing the glycoprotein for attachment to the host cell membrane.

Without this preparatory step, the HA complex is unable to properly position itself for the transfer of viral genetic material into a nearby host cell.

The anti-viral function of pure Australian Tea Tree Oil, as reported by two independent research teams (Li and Garozzo), is believed to act on the HA complex.

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Haemagglutinin (HA) Complex

Viruses contain an intricate combination of proteins and other structures embedded in their outer envelope. One of these is known as the haemagglutinin glycoprotein complex (HA complex).

The HA complex consists of several proteins that work together to facilitate binding to a host cell and the transfer of viral genetic material into the new host. While this system involves many complex interactions, the most important components are the HA1 and HA2 proteins.

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